Fosinopril Intermediate

Fosinopril Intermediate - Names and Identifiers

Name	[2-Methyl-l-(l-Oxopropoxy)Propoxy][(4-Phenylbutyl)Phosphinyl]Acetic Acid
Synonyms	Fosinopril intermediate rac-Des(4-cyclohexyl-L-proline) Fosinopril Acetic Acid [(2-Methyl-1-propionylpropoxy)(4-phenylbutyl)phosphinoyl]acetic acid [(2-Methyl-1-Propionylpropoxy)(4-Phenylbutyl)Phosphinoyl]Acetic Acid 2-(((2-Methyl-4-oxohexan-3-yl)oxy)(4-phenylbutyl)phosphoryl)acetic acid [[2-Methyl-l-(l-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid [2-Methyl-l-(l-Oxopropoxy)Propoxy][(4-Phenylbutyl)Phosphinyl]Acetic Acid 2-[(2-methyl-1-propanoyloxy-propoxy)-(4-phenylbutyl)phosphoryl]acetic acid rac-2-[[2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic Acid
CAS	123599-78-0
EINECS	602-944-4
InChI	InChI=1/C19H29O6P/c1-4-18(22)24-19(15(2)3)25-26(23,14-17(20)21)13-9-8-12-16-10-6-5-7-11-16/h5-7,10-11,15,19H,4,8-9,12-14H2,1-3H3,(H,20,21)

Fosinopril Intermediate - Physico-chemical Properties

Molecular Formula	C19H29O6P
Molar Mass	384.4
Density	1.153g/cm³
Melting Point	48 - 55°C
Boling Point	519.8°C at 760 mmHg
Flash Point	268.2°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	1.24E-11mmHg at 25°C
Appearance	Solid
Color	White to Off-White Low Melting
Storage Condition	2-8°C
Refractive Index	1.503

Fosinopril Intermediate - Introduction

[2-Methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid is an organic compound with the following properties:

1. appearance: the common form is colorless to light yellow liquid.
2. Solubility: It dissolves in many organic solvents, such as ethanol, ether and dichloromethane.
3. Stability: The compound is relatively stable to air and water, but may undergo decomposition reaction at high temperature.
4. odor: the compound has a pungent odor.

[2-methyl -1-(1-oxopropoxy) propoxy](4-phenyl butyl) phosphinyl] acetic acid is mainly used as follows:

1. Coordination reagent: It can be used as a ligand of metal complexes to form stable complexes with metals.
2. Catalyst: It can be used as a catalyst for organic synthesis reactions, such as the synthesis of oxalic esters.
3. Weather resistance additive: It can be used as an additive for polymers to improve their weather resistance and chemical corrosion resistance.

The method of preparing [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid includes the following steps:

1. Starting material: A compound of 2-methyl -1-(1-oxopropoxy) propanol and 4-phenylbutylpiperidine was obtained.
2. Preparation of phosphine compound: 2-methyl -1-(1-oxopropoxy) propanol is reacted with 4-phenylbutylpiperidine to generate [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine.
3. Rereaction: [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine is reacted with phosphine trichloride to give the final product [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid.

For safety information, the following precautions need to be observed:

1. Storage: The compound should be kept away from fire and oxidizing agents, and stored in a sealed container, away from direct sunlight.
2. use: when in use should pay attention to avoid inhalation, chewing or swallowing, contact with skin or eyes should immediately rinse with plenty of water.
3. Waste disposal: Local regulations should be followed to properly dispose of waste and not discharge it into water bodies or the environment.

Last Update：2024-04-09 20:02:46